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Misc. Medical News => Topic started by: Adminஐﻬ on January 18, 2011, 08:17:03 am => Misc. Medical News => Topic started by: Adminஐﻬ on January 18, 2011, 08:17:03 am|
Title: Does vitamin D affect risk of developing autoimmune disease? Post by: Adminஐﻬ on January 18, 2011, 08:17:03 am Does vitamin D affect risk of developing autoimmune disease?:
A systematic review Seminars in Arthritis and Rheumatism, 11/27/2010 Clinical Article Kriegel MA et al. – Cross-sectional data point to a potential role of vitamin D in autoimmune disease prevention, but prospective interventional evidence in humans is still lacking. Methods PubMed, limited to English from inception through April 2010, searched using keywords: “vitamin D,” “autoimmune,” and autoimmune disease names Summarized in vitro, animal, and genetic association studies of vitamin D in autoimmune disease pathogenesis Sorted epidemiologic studies by design and disease and performed systematic review of (a) cross-sectional data concerning vitamin D level and autoimmune disease; (b) interventional data on vitamin D supplementation in autoimmune diseases; and (c) prospective data linking vitamin D level or intake to autoimmune disease risk Results Vitamin D has effects on innate and acquired immune systems, and vitamin D receptor polymorphisms have been associated with various autoimmune diseases In experimental animal models, vitamin D supplementation can prevent or forestall autoimmune disease Of 1446 studies identified and screened, 76 studies examined vitamin D levels in autoimmune disease patients, particularly with active disease, and compared with controls 19 observational or interventional studies assessed effect of vitamin D supplementation as therapy for various autoimmune diseases (excluding psoriasis and vitiligo) with range of study approaches and results Few prospective human studies performed conflict as to whether vitamin D level or intake is associated with autoimmune disease risk No interventional trials investigated whether vitamin D affects human autoimmune disease risk
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