I am on Methotrexate, and have been on it for almost a year now. My doctor started me on it for RA and Lupus, but im sure they apply the same. I went to my doctor with severe pain and stiffness, he put me on it and within a few days I was feeling better, and I haven't had any Flare Ups since then. We've looked into the possability of stopping it and he says in six months I should be able to stop. My only problem with the medication is that it makes me nauseated and sometimes it leads to vomiting, but I take anti-nausea pills with it and it helps a lot. I wish you the best of luck, and hopefully this helps you make your decision.